Journal Information
Vol. 6. Issue 5.
Pages 395-425 (September - October 2000)
Download PDF
More article options
Vol. 6. Issue 5.
Pages 395-425 (September - October 2000)
DOI: 10.1016/S0873-2159(15)30927-2
Open Access
Normas de terapêutica inalatória*
Celeste Barreto**, Paula Pinto***, Filipe Froes****, Paula Cravo*****
** Assistente Hospitalar Graduada de Pediatria Médica do Serviço de Pediatria do Hospital de Santa Maria. Lisboa.
*** Assistente Hospitalar de Pneumologia do Departamento de Pneumologia do Hospital de Pulido Valente, Lisboa.
**** Assistente Hospitalar Graduado de Pneumologia do Departamento de Pneumologia do Hospital de Pulido Valente, Lisboa.
***** Assistente Eventual de Pneumologia da Unidade de Pneumologia do Hospital de São Bernardo, Setúbal.
Article information
Full text is only aviable in PDF
W.F. Miller.
Aerossol therapy in acute and chronic respimtory disease.
Arch Intern Med, 131 (1973), pp. 148-155
J.B. Graeser, A.H. Rowe.
lnhalation of epinephrine for relief of asthmatics symptoms.
J Allergy, 6 (1935), pp. 415-420
J. Denyer, D. Paiva, B. Zierenberg.
New liquid drug aerosol devices for inhalation therapy.
Eur Respir Rev, 10 (2000), pp. 72,187-72,191
P. Souef.
The meaning of lung dose.
Allergy, 54 (1999), pp. 93-96
Aerosol Consensus Statement.
Chest, 100 (1991), pp. 1106-1109
F. Frobs, M.C. Canteiro.
Aerossóis em Pneumologia.
Monografia do Departamento de Pneumologia do Hospital de Pulido Valente, (1992),
F. Faurisson.
La physique des aérosols est un jeu d’enfant.
L’ Aérosolthérapie par nebulisation en pnewnologie, pp. 11-15
D. Kohler, W. Fleischer.
Eslabli shed Facts in Inhalation Thempy.
Arcis-Verlag, (1991),
C. O Callagan, P. Barry.
The science of nebulized drug delivery.
Thorax, 52 (1997), pp. S31-S34
S. Ilowite, A. Fein.
Aerosol Thempy.
1st ed, pp. 1129-1137
A. Coates, S.L. Ho.
Drug Admnistration by Jet Nebulization.
Pediatr Pulmonol, 26 (1998), pp. 412-423
H. Chrystyn.
Anatomy and physiology in delivery: can we define our targets?.
Allergy, 54 (1999), pp. 82-87
H. Bisgaard.
Future options for aerosol delivery to children.
Allergy, 54 (1999), pp. 97-103
H. Bisgaard.
Patient-related factors in nebulized drug delivery to children.
Eur Resp J, 7 (1997), pp. 376-377
C. O’ Callaghan.
Delivery Systems.
Pediatr Pulmonol, 15 (1997), pp. 51-54
M. Dolovich.
Aerosol Delivery to children: What to Use, How to Use?.
Pediatr Pulmonol, 18 (1999), pp. 79-82
K. Grafschaft.
Different Aerosol Devices for Upper.
Lower and Alveolar Deposition. J Aerosol Med, 2 (1999), pp. 135
P. Zanen, L.T. Go, J.W.J. Lammers.
Optimal particle size for β2, agonist and anticholinergic aerosols in patients with severe airflow obstruction.
Thorax, 51 (1996), pp. 997-1080
F. Morén, M.B. Dolovich, M.T. Newhouse, S.P. Newman.
Aerossols in Medicine.
Diagnosis and Therapy, 2nd ed,
O. Selroos, A. Pietinalho, A.H. Risk.
Delivery Devices for Inhaled Asthma Medication.
Clin lmmunother, 6 (1996), pp. 273-299
R.M. Kacmarek, D. Hess.
The interface between patient and aerossol generator.
Respir Care, 36 (1991), pp. 952-976
G. Hucron.
Metered dose inhalers past and present: advantages and limitations.
Eur Respir Rev, 7 (1997), pp. 26-28
M.L. Everard, A.R. Clark, A.D. Mllner.
Drug delivery from holding chambers with attached facemask.
Archives of Disease in Cllildhood, 67 (1992), pp. 580-585
H. Levinson, P.A. Reilly, G.H. Worsley.
Spacing devices and metered-dose inhalers in childhood asthma.
The Journal of Pediatrics, Vol. 107 (November 1985),
G.K. Crompton, S. Duncan.
Clinical assessment of a new breath-activated inhaler.
The Practitioner, 233 (1989), pp. 268-270
P. Konig.
Spacer devices used with metered-doseinhalers. Breaktrough or gimmick?.
Chest, 88 (1985), pp. 276-284
BARRY PW, O’CALLAGHAN C. Inhaler devices for pre-school children. Pediatric, Respiratory Medicine 199; 1: 20–23.
J. Rivlin, C. Mindorff, et al.
Pulmonary response to a bronchodilatador delivered from three inhalation devices.
J Pediatrics, 3 (1984), pp. 470-473
F.M. Piérart, J.H. Wildhaber, I. Yrancken, et al.
Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery.
Eur Respir J, 13 (1999), pp. 673-678
G.K. Crompton.
New inhalation devices.
Eur Respir J, 1 (1988), pp. 679-680
S.P. Newman.
Lung deposition from nebulizers.
Eur Respir Rev, 10 (2000), pp. 224-227
K. Heslop, R. Harkawat.
Nebulizer therapy from a practical perspective.
Eur Respir Rev, 10 (2000), pp. 213-215
P. Diot, P. Bonfils, F. Faurisson, B. Fauroux, B. Dautzenberg.
Proposed guidelines for aerosol therapy by means of nebulizers in France.
Eur Rcspir Rev, 10 (2000), pp. 206-209
M. Knoch, E. Sommer.
Jet nebulizer des1gn and function.
Eur Respir Rev, 10 (2000), pp. 183-186
S. Deyadason, M. Everard, et al.
Comparasion of drug delivery from convencional versus “Venturi” nebulizers.
Eur Respir J, 10 (1997), pp. 2479-2483
G. Chantrel.
Therapeutic applications of nebulizers.
Eur Respir Rev, 10 (2000), pp. 199-202
M. Rosenfeld, M. Cohen, B. Ramsey.
Aerolized Antibiotics For Bacterial Lower Airway Infections: Principles, Efficacy.
And Pitfalls. lnfect Dis Clirucal Pratice, 7 (1998), pp. 66-79
A. Kendrick, E. Smith, R. Wtlson.
Selecting and using nebulizer equipment.
Thorax, 52 (1997), pp. S92-S101
M. Everard, A. Clark, A. Milner.
Drug delivery from jet nebullsers.
Arch Dis Child, 67 (1992), pp. 586-591
J. Mallol, S. Rattray, G. Walker, D. Cook, C.F. Robertson.
Aerosol Deposition in Infants with Cystic Fibrosis.
Pediatric PuJmonology, 21 (1996), pp. 276-281
H. Cbrystyn.
Pharmacokinetic methods to determine the lung deposition of nebulized drugs.
Eur Rcspir Rev, 10 (2000), pp. 228-231
M. Muers.
Overview of nebulizer treatment.
Thorax, 52 (1997), pp. S25-S30
M.T. Lopez-Vidrjero.
issues relating to safety and efficacy m nebulizer usc.
Eur Respir Rev, 10 (2000), pp. 210-212
T.A. Standaert, D. Vandevanter, B.W. Ramsey, M.K. Vasiljev, et al.
The choice of compressor effects the aerosol parameters and the delivery of tobramycin from single model nebulizer.
J Aerosol Med, 2 (2000), pp. 147-153
L. Lannefors.
Specific problems relating to restricted airways and patient adherence.
Eur Respir Rev, 10 (2000), pp. 216-219
C.J.P.M. Teirlinck.
Nebulizers in home health care: additional requirements with regard to product standardization.
Eur Respir Rev, 10 (2000), pp. 72,220-72,223
L.T. Rodwell, S.D. Anderson.
Airway Responsiveness to Hyperosmolar Saline Chalenge in Cystic Fibrosis: A Pilot Study.
Pedriat.ric Pulmonology, 21 (1996), pp. 282-289
British Thoracic Society.
The British guidelines on asthma management: Review and Position Statetnent.
Thorax, 52 (1997), pp. S1-S24
A.H. Idrls, M.F. McDermott, J.C. Raucci, et al.
Emergency department treatment of severe asthma. Metered-dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer.
Chest, 103 (1993), pp. 665-672
M.T. Newhouse.
Emergency department management of life-threatening asthma. Are nebulizers obsolete?.
Chest, 103 (1993), pp. 661-663
G.A. Salzman, M.T. Steele, R.M. Elenbaas, D.R. Pyszezynskj.
Aerosolized metaproterenol of asthmatics with severe airtlow obstruction: comparison of two delivery methods.
Chest, 95 (1989), pp. 1017-1020
R.V. Hodder, L.E. Calcutt, J.A. Leach.
Metered dose inhaler with spacer is superior to wet nebulization for emergency room treatment of acute severe asthma.
Chest, 94 (1988), pp. 52S
A. Colacone, M. Afilalo, N. Wolkove, H. Kreisman.
Dose response to inhaled salbutamol administered by metered dose inhaler or wet nebulizer in the treatment of acute asthma.
Am Rev Respir Dis, 143 (1991), pp. A650
B. Littenberg.
Aminophyline treatment in severe acute asthma.
A meta-analysis. JAMA, 259 (1988), pp. 1678-1684
B.M.Z. Zainudid, O. Ismail, K. Yusoff.
Effect of adding aminophyline infusion to nebulized salbul.amol in severe acute asthma.
Thorax, 49 (1994), pp. 267-269
P. Lawford, B.J.M. Jones, J.S. Milledge.
Comparison of intravenous and nebulized salbutamol in initial treatment of severe asthma.
BMJ, 7 (1978), pp. 81-84
Swedish Society Of Chest Medicine.
High dose inhaled versus intravenous salbutamol combined with aminophyline in severe acute asthma.
Eur Respir J, 3 (1990), pp. 163-170
D. Van Renterghem, H. Lamont, W. Elink, R. Pauwels, M. Vander Straeten.
Intravenous versus nebulized terbutaline in patients with acute severe asthma: a double blind randomized study.
Ann Allergy, 59 (1987), pp. 313-316
M.J. Ward, P.H. Fentem, W.R.H. Smith, D. Davies.
Ipratropium bromide in acute asthma.
BMJ, 282 (1981), pp. 598-600
B.R. O’ Driscoll, R.J. Taylor, M.G. Horsley, D.K. Chambers.
Bernstein A. Nebulized salbutamol with and without iprntropium bromide in acute airnow.
Lancet, 7 (1989), pp. 1418-1420
P.H. Mann, J.S. Howarth, S.T. Holgate.
Bronchoconstriction induced by ipratropium bromide in asthma: relation to hypotonicity.
BMJ, 298 (1984), pp. 465-469
J.G. Douglas, P. Rafferty, R.J. Fergusson, R.J. Prescott, G.K. Crompton, I.W.B. Grant.
Nebulized salbutamol without oxygen in severe asthma: how effective and how safe?.
Thorax, 40 (1985), pp. 180-183
D.J. Lane.
Chronic persistent asthma: ncbu.lizcrs and therapy additional to inhaled beta agonists and steroids.
Respir Med, 85 (1991), pp. 359-363
National Heart, Lung, And Blood Lnstitute.
Global lniciati ve for Asthma.
The nebulizer Project Group of the British Thoracic Society Standards of Care Committee. Current best practice for nebuliser treatment.
Thorax, 52 (1997), pp. S45-S52
ATS Statement, Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease.
Am J Rcspir Crit Care Med, 152 (1995), pp. S78-S121
ERS. Consensus Statement. Optimal assessment and management of chronic obstructi ve pulmonary disease (COPD).
Eur Rcspir J, 8 (1995), pp. 1398-1420
B.B. Richard, et al.
Nebuli zer vs spacer for bronchodilatator delivery in patients hospitalized for acute exacerbations of COPD.
Chest, 96 (1989), pp. 1241-1246
B.R. O’ Driscoll, E.A. Kay, R.J. Taylor, H. Weatherby, M.C.P. Chetty, A. Bernsteln.
A long-term prospective assessment of home nebuliser treatment.
Respir Med, 86 (1992), pp. 317-325
B.R. O’ Driscoll.
Home ncbulised therapy- is it effective?.
Respir Med, 85 (1991), pp. 1-3
J.M. Goldman, C. Teale, M.F. Moers.
Simplifying the assessment of patients with chronic airnow limitation for home ncbuliser therapy.
Respir Med, 86 (1992), pp. 33-38
J.F.J. Morrison, P.C. Jones, M.F. Muers.
Assessing physiological benclit from domiciliary nebulised bronchodilators in severe airnow limitation.
Bur Respir J, 5 (1992), pp. 424-429
C. Toso, D.M. Williams, P.G. Noone.
Inhaled Antibiotics in Cystic Fibrosis: 3 Review.
Ann Pharmacother, 30 (1996), pp. 840-850
A.K. Webb, M.E. Dodd.
Nebulised antibiotics for adults with cystic fibrosis.
Thorax, 52 (1997), pp. S69-S71
A. Weber, G. Morlin, M. Cohen, J. Williams­Warren, B. Ramsey, A. Smith.
Effect of Nebulizer Type and Antibiotic Concentration on Device Performance.
Pediatric Pulmonology, 23 (1997), pp. 249-260
D.M. Geddes.
Nebulized therapy and cystic fibrosis.
Eur Respir Rev, 7 (1997), pp. 173-176
D. Spencer.
Nebuliscd bronchodilators, antibiotics and rhDNase for children with cystic fibrosis.
Thorax, 52 (1997), pp. S89-S91
S. Conway, A. Watson.
Nebulised bronchodilators, antibiotics and rhDNase in adult patients with cystic fibrosis.
Thorax, 52 (1997), pp. S64-S68
P.W. Campbell III, L. Salman.
Use of aerosoli zed antibiotics in patients with cystic fribrosis.
Chest, 116 (1999), pp. 775-788
B. Frederiksen, C. Koch, N. Hoiby.
Antibiotic treatment of initial colonization with Pseudomonas acruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fybrosis.
Pediatric Pulmonology, 23 (1997), pp. 330-335
M.S. Pepe, J.M. Quan, et al.
fntcm1ittent administration of inhaled tobramycin in patients with Cystic Fibrosis. For the Cystic Fibrosis Inhaled Tobramycin Study Group.
N Engl J Med, 340 (1999), pp. 23-30
J.O. Warner, C.K. Naspitz, G.I. Cropp, et al.
Third International Pediatric Consensus Statement on the Management of Childhood Asthma.
Ped Pulmonol, 25 (1998), pp. 1-17
P.W. Barry, C. O’Callaghan.
The output of budesonide from nebuli zers.
J Allergy Clin Immunol, (August 1998),
M. Zak, J. Madsen, E. Berg, J. Bulow, H. Bisgaard.
A mathematical model of aerosol holding chambers.
Joumal of Aerosol Medicine, 3 (1999), pp. 187-196
J.M. César Ramos.
Asma da criança-novas perspectivas.
Cademos de lmuno-Aiergologia Pediátrica, 1 (1998), pp. 21-29
R. Anjos, T. Bandeira, J.G. Marques.
Fonnulario de Pedintria, 2* ed,
N. Ferreira.
Agir em 5 minutos na Asma Bropnquica da Criança.
Protocolos de Urgencia-Pediatria, 1* ed,
C.G. Pinto, T. Bandeira, R. Estrjdo, M. Correia, A. Levy Gomes, P. Oom, J.C. Gomes Pedro.
Protocolos de Urgencia-Pediatria, 1a ed,
A.S. Branco, M. Pequfto, T. Bandeira.
Bronquiolite aguda.
Protocolos de Urgencia-Pediatria, 1a ed,
J.M. Armitage, S.J. Williams.
Inhaler technique in the elderly.
Age Ageing, 17 (1988), pp. 275-278
S.C. Allen, A. Prior.
What determines whether an elderly patient can use a metered dose inhaler correctly?.
Br J Dis Chest, 80 (1986), pp. 45-49
P. Diggory, R. Bailey, A. Vallon.
Effectiveness of inhaled bronchodilator delivery systems for elderly patients.
Age Ageing, 20 (1991), pp. 379-382
M.I. Ullah, G.B. Newman, K.B. Saunders.
lnfluence of age on response to ipratropium and salbutamol in asthma.
Thorax, 36 (1981), pp. 523-529
P. Sah, L. Dhurjon, T. Metcalfe, J.M. Gibson.
Acute angle closure glaucoma associated with nebulised ipratropium and salbutamol.
BMJ, 304 (1992), pp. 40-41
M.J. Tobin, R. Dhand.
Bronchodilator delivery with metered-dose inhalers in mechanically-ventilated patients.
Eur Respir J, 9 (1996), pp. 585-595
S.J. Crogan, M.J. Bishop.
Delivery efficiency of metered-dose aerosols given via endotracheal tubes.
Anesthesiology, 70 (1989), pp. 1008-1010
H.D. Fuller, M.B. Dolovich, F.H. Turpie, M.T. Newhouse.
Efficiency of bronchodilatador aerosol delivery to the lungs from the metered-dose inhaler in mechanically-ventilated patients: a study comparing four different actuator devices.
Chest, 105 (1994), pp. 214-218
C.A. Manthous, J.B. Hall, G.A. Schmidt, L.D.H. Wood.
Metered-dose inhaler versus nebulized albuterol in mechanically ventilated patients.
Am Rev Rcspir Dis, 148 (1993), pp. 1567-1570
N.J. Gross, J.W. Jenne, D. Hess.
Bronchodilator Therapy.
Principles and Practice of Mechanical Ventilation, 1a edition, pp. 1077-1123
T.G. O’ Riordan, L.B. Palmer, G.C. Smaldone.
Aerosol deposition in mmechanically-ventilated patients: optimizing nebuli zer delivery.
Arn J Respir Crit Care Med, 149 (1994), pp. 214-219
The Nebulizer Project Group of the British Thoracic Society Standards of Care Commillce. Current best practice for nebuliser treatment.
Thorax, 52 (1997), pp. S1-S106
J. Ginner, L.V. Basualdo, P. Casan, et al.
Nonnativa SEPAR. Nonnativa sobre Ia utilizaci6n de f6rmacos inhalados.
Arch Bronconcumol, 36 (2000), pp. 34-43
B. Dautzenbero, P. Bonfils, P. Diot, B. Fauroux, F. Faurjsson.
Propositi ons de boones pratiques de l’aerosoltherapie par nebulisation.
Margaux Orange, (1997),
Review of methodology and development of UK nebulizer guidelines (1997) prepared by British Thoracic Society.
Eur Respir Rev, 10 (2000), pp. 203-205

Socicdade Porruguesa de Pneumologia. Comissão de Reabilitação Respirntócia Grupo de lnalotcmpia

Copyright © 2000. Sociedade Portuguesa de Pneumologia/SPP

Subscribe to our newsletter

Article options

Are you a health professional able to prescribe or dispense drugs?