Journal Information
Vol. 6. Issue 3.
Pages 187-193 (May - June 2000)
Share
Share
Download PDF
More article options
Vol. 6. Issue 3.
Pages 187-193 (May - June 2000)
PALESTRA/LECTURE
Open Access
Diferenciais celulares e subpopulações linfocitárias no LBA da pneumonia de hipersensibilidade
Bronchoalveolar Lavage Cell Differentials and Lymphocyte Subsets in Hypersensitivity Pneumonitis
Visits
4248
Ulrich Costabel
Essen, Germany
This item has received

Under a Creative Commons license
Article information
RESUMO

Fazse uma profunda revisão das características do Lavado Broncoalveolar nas Pneumonias de Hipersensibilidade (PH). Discute-se o perfil do LBA nas diferentes fases de PH, da relação T4/T8 e dos marcadores de actividades dos linfocitos. Seguidamente são apresentados os resultados do LBA em indivíduos expostos assintomáticos e os padrões de alveolite que aparecem no follow-up destes doentes. Finalmente defendese a relevância diagnóstica de LBA na Pneumonia de Hipersensibilidade.

REV PORT PNEUMOL 2000; VI (3): 187-193

Palavras-chave:
LBA
subpopulações linfocitárias
pneumonia de hipersensiblidade
ABSTRACT

A thorough review on BAL data in hipersensitivity pneumonitis (HP) is made. The HAL cell profile on the different phases of HP is discussed, the CD4/CD8 ratio, the lung Tcell murkers of activation. Then the BAL findings in asymptomatic exposed Individual are addressed as the pattern of alveolitis during follow-up. Finally the diugnostic relevance of the BAL findings in HP is defended.

REV PORT PNEUMOL 2000; VI (3): 187-193

Key-words:
BAL
Limphocyte subsets
Hypersensitivity pneumonitis
Full text is only aviable in PDF
BIBLIOGRAFIA
[1.]
H.Y. Reynolds, J.D. Fulmer, J.A. Kazmierowski, W.C. Roberts, M.M. Frank, R.G. Crystal.
Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.
J Clin Invest., 59 (1977), pp. 165-175
[2.]
J.W. Leatherman, A.F. Michael, B.A. Schwartz, J.R. Hoidal.
Lung T cell in hypersensitivity pneumonitis.
Ann Intern Med, 100 (1984), pp. 390-392
[3.]
U.K. Costabel, J. Bross, K.H. Ruhle, G.W. Ldhr, H. Matthys.
La-like antigens on T-cells and their subpopulations in pulmonary sarcoidosis and in hypersensitivity pneumonitis.
Analysis of bronchoalveolar and blood lymphocytes. Am Rev Respir Dis., 131 (1985), pp. 337-342
[4.]
G. Semenzato, C. Agostini, H. Zambello, L. Trentin, M. Chilosi, G. Pizzolo, G. Marcer, A. Cipriani.
Lung T cells in hypersensitivity pneumonitis: phenotypie and functional analyse.
J Immunol., 137 (1986), pp. 1164-1172
[5.]
P. Soler, S. Nioche, D. Valeyre, F. Basset, J. Benveniste, C. Burtin, J.P. Battesti, R. Georges, A.J. Hance.
Role of mast cells in the pathogenesis of hypersensitivity pneumonitis.
Thorax., 42 (1987), pp. 565-572
[6.]
M.A. Johnson, A. Nemeth, A. Condez, S.W. Clarke, L.W. Poulter.
Cellmediated immunity in pigeon breeders’ lung: the effect of removal from antigen exposure.
Eur Respir J, 2 (1989), pp. 445-450
[7.]
A. Pesci, G. Bertorelli, D. Olivieri.
Mast cells in bronchoalveolar lavage fluid and in transbronchial biopsy specimens of patients with farmer’s lung disease.
Chest., 100 (1991), pp. 1197-1202
[8.]
M. Laviolette, Y. Cormier, A. Loiseau, P. Soler, P. Leblanc, A.J. Hance.
Bronchoalveolar mast cells in normal fanners and subjects with farmer’s lung. Diagnostic, prognostic, and physiologic significance.
Am Rev Respir Dis, 144 (1991), pp. 855-860
[9.]
M. Drent, H. Van Velzen-Blad, M. Diamant, S.S. Wagenaar, H.C. Hoogsteden, J.M. Van Den Bosch.
Bronchoalveolar lavage in extrinsic allergic alveolitis: effect of time elapsed since antigen exposure.
Eur Respir J, 6 (1993), pp. 1276-1281
[10.]
E. Fournier, A.B. Tonnel, W. Gossetp, B. Allaert, J.C. Ameisen, C. Voisin.
Early neutrophil alveolitis after antigen inhalation in hypersensitivity pneumonitis.
Chest, 88 (1985), pp. 563-566
[11.]
M. Rust, G. Schultze-Werninghaus, G. Schultze-Werninghaus, J. Meier-Sydow.
Bronchoalveolar lavage as a tool to assess an inhalative provocation in extrinsic allergic alveolitis.
Prax Klin Pneumol, 40 (1986), pp. 229-232
[12.]
U. Costabel, K.J. Bross, J. Guzman, H. Matthys.
Plasmazellen und Lymphozytensubpopulationen in der bronchoalveoälren Lavage bei exogen-allergischer Alveolitis.
Prax. Klin. Pneumol., 39 (1985), pp. 925-926
[13.]
M. Drent, S. Wagenaar, H. Van Velzen-Blad, P.G. Mulder, H.C. Hoogsteden, J.M. Van Den Bosch.
Relationship between plasma cell levels and profile of bronchoalveolar lavage tluid in patients with subacute extrinsic allergic alveolitis.
Thorax, 48 (1993), pp. 835-839
[14.]
U. Costabel, H. Teschler, J. Guzman.
Bronchiolitis obliterans organizing pneumonia (BOOP): the cytological and immunocytological profile of bronchoalveolar lavage.
Eur Respir J., 5 (1992), pp. 791-797
[15.]
M. Ando, K. Konishi, R. Yoneda, M. Tamura.
Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer’s lung. ventilation pneumonitis, and bird fancier’s lung: report of a nationwide epidemiologic study in Japan.
J Allergy Clin (mmunol, 87 (1991), pp. 1002-1009
[16.]
R.H. Keller, S. Swartz, D.P. Schlueter, S. Bar-Sela, J.N. Fink.
Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalvcolar lavage lymphocytes.
Am Rev Respir Dis, 130 (1984), pp. 766-771
[17.]
S.P. Reynolds, K.P. Jones, J.H. Edwards, B.H. Davies.
Immunoregulatory proteins in bronchoalveolar lavage fluid. A comparative analysis of pigeon breeders’ disease, sarcoidosis and idiopathic pulmonary fibrosis.
Sarcoidosis, 6 (1989), pp. 125-134
[18.]
U. Costabel, H. Teschler, C.P. Bauer.
Stellenwert der bronchoalveolaren Lavage bei exogen-allergischer Alveolitis.
Atermw-Lungenkrkh., 15 (1989), pp. 598-604
[19.]
L. Trentin, N. Migone, R. Zambello, P.F. Di Celle, F. Aina, C. Feruglio, P. Bulian, M. Masciarelli, C. Agostini, A. Cipriani, et al.
Mechanisms accounting for lymphocytic alveolitis in hypersensitivity pneumonitis.
J Immunology, 145 (1990), pp. 2147-2154
[20.]
P. Solal-Celigny, M. Laviolette, J. Hebert, Y. Cormier.
Immune reactions in the lungs of asymptomatic dairy farmers.
Am Rev Respir Dis, 126 (1982), pp. 964-967
[21.]
Y. Cormier, J. Belanger, M. Laviolette.
Persistent bronchoalveofar lymphocytosis in asymptomatic fanners.
Am Rev Respir Dis, 133 (1986), pp. 843-847
[22.]
L. Trentin, G. Marcer, M. Chilosi, R. Zambello, C. Agostini, M. Masciarelli, R. Bizzotto, C. Gemignani, A. Cipriani, G. Di Vittorio, et al.
Longitudinal study of alveolitis in hypersensitivity pneumonitis patients: an immunologic evaluation.
J Allergy Clin Immunol, 82 (1988), pp. 577-585
[23.]
U. Costabel, J. Guzman, S. Seyboth, K. Ruhle, H. Matthys.
Serial anlaysis of lung lymphocytes and T-cell subsets during the course of hypersensitivity pneumonitis.
Am Rev Respir Dis, 135 (1987), pp. 372A
[24.]
G. Semenzato, L. Bjermer, U. Costabel, P.L. Haslam, D. Olivieri.
Clinical guidelines and indications for bronchoalveolar lavage (BAL): extrinsic allergic alveolitis.
Eur Respir J., 3 (1990), pp. 961-969
Copyright © 2000. Sociedade Portuguesa de Pneumologia/SPP
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?