TY - JOUR T1 - Chronic granulomatous disease associated with common variable immunodeficiency – 2 clinical cases JO - Pulmonology T2 - AU - Pacheco,C. AU - Morais,A. AU - Rolo,R. AU - Ferreira,L. AU - Nabiço,R. AU - Cunha,J. SN - 08732159 M3 - 10.1016/j.rppneu.2013.09.005 DO - 10.1016/j.rppneu.2013.09.005 UR - https://www.journalpulmonology.org/pt-chronic-granulomatous-disease-associated-with-articulo-S0873215913001591 AB - IntroductionChronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. Clinical casesCase 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy.Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. ConclusionGD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge. ER -