Original article
Alpha-1 antitrypsin deficiency and Pi*S and Pi*Z SERPINA1 variants are associated with asthma exacerbations
Elena Martín-Gonzáleza, José M. Hernández-Pérezb,c, José A. Pérez Péreza,d, Javier Pérez-Garcíaa, Esther Herrera-Luisa, Ruperto González-Péreze,f, Orelvis González-Gonzálezg, Elena Mederos-Luise, Inmaculada Sánchez-Machíne, Paloma Poza-Guedese,f, Olaia Sardónh,i, Paula Corcuerah, María J. Cruzj,k, Francisco J. González-Barcalal, Carlos Martínez-Riverak,m, Joaquim Mullolk,n, Xavier Muñozj,k, José M. Olaguibelk,o, Vicente Plazak,p, Santiago Quircek,q..., Antonio Valerok,r, Joaquín Sastrek,s, Javier Korta-Muruah, Victoria del Pozok,t, Fabián Lorenzo-Díaza,d, Jesús Villark,u, María Pino-Yanesa,k,v,
, Mario A. González-Carracedoa,d,
Ver más
Corresponding author
mdelpino@ull.edu.es
Corresponding authors at: Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL). Apartado 456, La Laguna, 38200 Santa Cruz de Tenerife, Spain.
Corresponding authors at: Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL). Apartado 456, La Laguna, 38200 Santa Cruz de Tenerife, Spain.
Corresponding author
mgonzalc@ull.edu.es
Corresponding authors at: Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL). Apartado 456, La Laguna, 38200 Santa Cruz de Tenerife, Spain.
Corresponding authors at: Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna (ULL). Apartado 456, La Laguna, 38200 Santa Cruz de Tenerife, Spain.
a Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), 38200 La Laguna, Tenerife, Spain
b Department of Respiratory Medicine, Hospital Universitario de N.S de Candelaria, 38010 Santa Cruz de Tenerife, Spain
c Respiratory Medicine, Hospital Universitario de La Palma, 38713 Breña Alta, Santa Cruz de Tenerife, Spain
d Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain
e Allergy Department, Hospital Universitario de Canarias, 38320 La Laguna, Tenerife, Spain
f Severe Asthma Unit, Allergy Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain
g Hospital Universitario de La Palma, 38713 Breña Alta, Santa Cruz de Tenerife, Spain
h Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain
i Department of Pediatrics, University of the Basque Country (UPV/EHU), San Sebastián, Spain
j Department of Respiratory Medicine, Hospital Vall d'Hebron, Barcelona, Spain
k CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
l Department of Respiratory Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, Spain
m Department of Respiratory Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
n Rhinology Unit & Smell Clinic, ENT Department, Clinical and Experimental Respiratory Immunoallergy (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
o Department of Allergy, Hospital Universitario de Navarra, Pamplona, Navarra, Spain
p Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
q Department of Allergy, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
r Allergy Unit & Severe Asthma Unit, Pneumonology and Allergy Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
s Department of Allergy, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
t Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
u Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain
v Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain
Ver másRead
9836
Timeswas read the article
1431
Total PDF
8405
Total HTML
| Year/Month | Html | Total | |
|---|---|---|---|
| 2025 12 | 207 | 13 | 220 |
| 2025 11 | 1112 | 64 | 1176 |
| 2025 10 | 1031 | 62 | 1093 |
| 2025 9 | 848 | 41 | 889 |
| 2025 8 | 682 | 71 | 753 |
| 2025 7 | 454 | 79 | 533 |
| 2025 6 | 394 | 49 | 443 |
| 2025 5 | 370 | 50 | 420 |
| 2025 4 | 448 | 46 | 494 |
| 2025 3 | 434 | 45 | 479 |
| 2025 2 | 220 | 38 | 258 |
| 2025 1 | 170 | 41 | 211 |
| 2024 12 | 140 | 43 | 183 |
| 2024 11 | 195 | 44 | 239 |
| 2024 10 | 163 | 68 | 231 |
| 2024 9 | 170 | 53 | 223 |
| 2024 8 | 196 | 69 | 265 |
| 2024 7 | 195 | 66 | 261 |
| 2024 6 | 152 | 53 | 205 |
| 2024 5 | 184 | 54 | 238 |
| 2024 4 | 116 | 47 | 163 |
| 2024 3 | 112 | 29 | 141 |
| 2024 2 | 68 | 36 | 104 |
| 2024 1 | 56 | 24 | 80 |
| 2023 12 | 44 | 30 | 74 |
| 2023 11 | 52 | 37 | 89 |
| 2023 10 | 42 | 43 | 85 |
| 2023 9 | 42 | 36 | 78 |
| 2023 8 | 22 | 7 | 29 |
| 2023 7 | 24 | 29 | 53 |
| 2023 6 | 43 | 51 | 94 |
| 2023 5 | 19 | 13 | 32 |
Show all
