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Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort
S. Koiralaa,*, S. Borisovb,*, E. Danilac,*, A. Mariandyshevd, B. Shresthae, N. Lukhelef, M. Dalcolmog, S.R. Shakyah, S. Miliauskasi, L. Kuksaj, S. Mangak, A. Aleksal, J.T. Denholmm, H.B. Khadkan, A. Skrahinao, S. Diktanasp, M. Ferrareseq, J. Bruchfeldr, A. Kolevas, A. Piubellot, G.S. Koiralau, Z.F. Udwadiav, D.J. Palmerow, M. Munoz-Torricox, R. GCy, G. Gualanoz, V.I. GrecuA, I. MottaB, A. PapavasileiouC, Y. LiD, W. HoefslootE, H. KunstF, J. Mazza-StalderG, M.-C. PayenH, O.W. AkkermanI,J, E. BernalK, V. ManfrinL, A. MatteelliM, H. Mustafa HamdanN, M. Nieto MarcosO, J. Cadiñanos LoidiP, J.J. Cebrian GallardoQ, R. DuarteR, N. Escobar SalinasS, R. Gomez RossoT, R. Laniado-LaborínU,V, E. Martínez RoblesW, S. Quirós FernandezX, A. RendonY, I. SolovicZ, M. Tadoliniaa,bb, P. Viggianicc, E. Belilovskib, M.J. BoereeE, Q. Caidd, E. Davidavičienėee,ff, L.D. Forsmanr, J. De Los Riosgg, J. Drakšienėp, A. Dugahh,ii, S.E. ElaminN, A. Filippovb, A. Garciaw, I. Gaudiesiutei, B. Gavazovajj, R. Gayosog, V. Gruslysc, J. Jonssonkk, E. Khimovad, G. Madonselall, C. Magis-EscurraE, V. MarcheseM, M. Mateimm,nn, C. MoschosC, B. Nakčerienėee,ff, L. NicodG, F. Palmieriz, A. Pontarellioo, A. Šmitej, M.B. Souleymanet, M. Vescovow, R. Zablockisc, D. Zhurkino, J.-W. Alffenaarpp,qq,rr, J.A. Camineross,tt, L.R. Codecasaq, J.-M. García-Garcíauu, S. Espositovv, L. Saderiww, A. Spanevelloxx,yy, D. Viscaxx,yy, S. TiberiF,zz, E. PontaliAA, R. CentisBB, L. D'AmbrosioCC, M. van den BoomDD, G. Sotgiuww, G.B. MiglioriBB,
Corresponding author
giovannibattista.migliori@icsmaugeri.it

Corresponding author at: Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Via Roncaccio 16, Tradate, Varese, 21049, Italy.
a Damien Foundation Nepal, Kathmandu, Nepal
b Moscow Research and Clinical Center for TB Control, Moscow Government’s Health Department, Moscow, Russian Federation
c Clinic of Chest Diseases, Immunology and Allergology, Vilnius University Medical Faculty, Centre of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
d Northern State Medical University, Northern (Arctic) Federal University, Arkhangelsk, Russian Federation
e Kalimati Chest Hospital/GENETUP/Nepal Anti Tuberculosis Association, Kathmandu, Nepal
f TB/HIV, Hepatitis, & PMTCT Department, World Health Organization, Eswatini WHO Country Office, Mbabane, Eswatini
g Reference Center Hélio Fraga, Fundação Oswaldo Cruz (Fiocruz)/Ministry of Health, Rio de Janeiro, Brazil
h Lumbini Provincial Hospital, Butwal, Nepal
i Department of Pulmonology, Lithuanian University of Health Sciences, Kaunas, Lithuania
j MDR-TB Department, Riga East University Hospital for TB and Lung Disease Centre, Riga, Latvia
k Department of Infectious Diseases, University National San Antonio Abad Cusco, Cusco, Peru
l Department of Phthisiology and Pulmonology, Grodno State Medical University, Grodno, Belarus
m Victorian Tuberculosis Program, Melbourne Health, Department of Infectious Diseases, University of Melbourne, Melbourne, Australia
n Nepalgjunj TB Referral Center, TB Nepal, Nepalgunj, Nepal
o Republican Research and Practical Centre for Pulmonology and Tuberculosis, Minsk, Belarus
p Tuberculosis Department, 3rd Tuberculosis Unit, Republican Klaipėda Hospital, Klaipėda, Lithuania
q TB Reference Centre, Villa Marelli Institute, Niguarda Hospital, Milan, Italy
r Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institute, Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
s Pulmonology and Physiotherapy Department, Gabrovo Lung Diseases Hospital, Gabrovo, Bulgaria
t Damien Foundation, Niamey, Niger
u Nepal Anti Tuberculosis Association, Morang Branch, TB Clinic, Biratnagar, Province 1, Nepal
v Department of Respiratory Medicine, P.D. Hinduja National Hospital and MRC, Mumbai, India
w Pulmonology Division, Municipal Hospital F. J. Muñiz, Buenos Aires, Argentina
x Clínica de Tuberculosis, Instituto Nacional De Enfermedades Respiratorias Ismael Cosio Villegas, Ciudad De Mexico, Mexico
y Damien Foundation, Midpoint District Community Memorial Hospital, Danda, Nawalparasi, Nepal
z Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases ‘L. Spallanzani’, IRCCS, Rome, Italy
A National Programme for Prevention, Surveillance and Control of Tuberculosis, Dolj Province, Romania
B Department of Medical Science, Unit of Infectious Diseases, University of Torino, Italy
C Department of Tuberculosis, Sotiria Athens Hospital of Chest Diseases, Athens, Greece
D Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China
E Radboud University Medical Center, Center Dekkerswald, Nijmegen, The Netherlands
F Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
G Division of Pulmonary Medicine, University Hospital of Lausanne CHUV, Lausanne, Switzerland
H Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
I University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, Groningen, The Netherlands
J University of Groningen, University Medical Center Groningen, TB Center Beatrixoord, Haren, The Netherlands
K Unidad de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, Murcia, Spain
L Infectious and Tropical Diseases Operating Unit, S. Bortolo Hospital, Vicenza, Italy
M Clinic of Infectious and Tropical Diseases, WHO Collaborating Centre for TB Elimination and TB/HIV Co-infection, University of Brescia, Brescia, Italy
N MDR-TB Department, Abu Anga Teaching Hospital, Khartoum, Sudan
O Internal Medicine Department, Hospital Doctor Moliner, Valencia, Spain
P Internal Medicine Department, Hospital General de Villalba, Collado Villalba, Spain
Q Unidad de Neumología, Agencia Sanitaria Costa del Sol, Marbella, Spain
R National Reference Centre for MDR-TB, Hospital Centre Vila Nova de Gaia, Department of Pneumology, Public Health Science and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal
S Division of Disease Prevention and Control, Department of Communicable Diseases, National Tuberculosis Control and Elimination Programme, Ministry of Health, Santiago, Chile
T National Institute of Respiratory and Environmental Diseases ¨Prof. Dr. Juan Max Boettner¨ Asunción, Paraguay
U Universidad Autónoma de Baja California, Baja California, Mexico
V Clínica de Tuberculosis del Hospital General de Tijuana, Tijuana, Baja California, Mexico
W Internal Medicine Department, Hospital de Cantoblanco- Hospital General Universitario La Paz, Madrid, Spain
X Pneumology Department, Tuberculosis Unit, Hospital de Cantoblanco- Hospital General Universitario La Paz, Madrid, Spain
Y Centro de Investigación, Prevención y Tratamiento de Infecciones Respiratorias CIPTIR, University Hospital of Monterrey UANL (Universidad Autonoma de Nuevo Leon), Monterrey, Mexico
Z National Institute for TB, Lung Diseases and Thoracic Surgery, Vysne Hagy, Catholic University Ruzomberok, Slovakia
aa Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant’Orsola, Bologna, Italy
bb Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna, Bologna, Italy
cc Reference Center for MDR-TB and HIV-TB, Eugenio Morelli Hospital, Sondalo, Italy
dd Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou, China
ee National TB Registry, Public Health Department, Ministry of Health, Vilnius, Lithuania
ff Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
gg Centro de Excelencia de TBMDR, Hospital Nacional Maria Auxiliadora, Lima, Peru
hh Baylor College of Medicine, Children’s Foundation, Mbabane, Eswatini
ii National Pharmacovigilance Center, Eswatini Ministry of Health, Matsapha, Eswatini
jj Improve the Sustainability of the National TB Programme, Sofia, Bulgaria
kk Department of Public Health Analysis and Data Management, Public Health Agency of Sweden, Solna, Sweden
ll Eswatini National Aids Programme, Mbabane, Eswatini
mm Hospital of Pneumophtisiology Leamna, Dolj Province, Romania
nn University of Medicine and Pharmacy, Craiova, Romania
oo Respiratory Infectious Diseases Unit, Cotugno Hospital, A.O.R.N. dei Colli, Naples, Italy
pp University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, Australia
qq Westmead Hospital, Sydney, Australia
rr Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
ss Pneumology Department, Hospital General de Gran Canaria “Dr. Negrin”, Las Palmas de Gran Canaria, Spain
tt Vital Strategies, New York, USA
uu Tuberculosis Research Programme (PII-TB), SEPAR, Barcelona, Spain
vv Pediatric Clinic, Pietro Barilla Children’s Hospital, University of Parma, Parma, Italy
ww Clinical Epidemiology and Medical Statistics Unit, Department of z, University of Sassari, Sassari, Italy
xx Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy
yy Department of Medicine and Surgery, Respiratory Diseases, University of Insubria, Tradate, Varese-Como, Italy
zz Department of Infection, Royal London and Newham Hospitals, Barts Health NHS Trust, London, United Kingdom
AA Department of Infectious Diseases, Galliera Hospital, Genova, Italy
BB Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy
CC Public Health Consulting Group, Lugano, Switzerland
DD World Health Organization Regional office for Europe, Copenhagen, Denmark
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