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Vol. 13. Issue 3.
Pages 365-376 (May - June 2007)
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Vol. 13. Issue 3.
Pages 365-376 (May - June 2007)
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Células reguladoras
Regulatory cells
Visits
794
Luís Miguel Borrego1,
, Sónia Rosa2, Cármen Algueró3, Hélder Trindade4, José Rosado Pinto5, Rua Jacinta Marto6
1 Assistente Hospitalar de Imunoalergologia. Serviço de Imunoalergologia do Hospital de Dona Estefânia. Assistente Convidado do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa
2 Interna do Internato Complementar de Imunoalergologia. Serviço de Imunoalergologia do Hospital de Dona Estefânia
3 Assistente Convidada do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa
4 Professor Associado Convidado com Agregação do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa
5 Responsável pelo Serviço de Imunoalergologia do Hospital de Dona Estefânia. Professor Auxiliar convidado da Faculdade de Ciências Médicas de Lisboa
6 Serviço de Imunoalergologia – Hospital de Dona Estefânia: Rua Jacinta Marto – 169-045 Lisboa, Tel: +351213126600 / Fax: +351213126654
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Resumo

O papel das células T reguladoras na indução e manutenção da tolerância periférica tem recebido uma atenção crescente nos últimos anos. Foram descritos vários subgrupos de células T reguladoras, com base em marcadores de superfície e na produção de citocinas, não havendo no entanto marcadores específicos para nenhum destes subgrupos, pelo que a sua classificação se baseia no seu mecanismo de supressão.

Desconhece-se qual dos subgrupos de células T reguladoras terá papel preponderante na prevenção e controlo das doenças alérgicas, sendo no entanto consensual a sua importância para a homeostasia.

Palavras-chave:
Doenças alérgicas
células T reguladoras
tolerância periférica
Abstract

The role of regulatory T cells in the induction and maintenance of peripheral tolerance has received growing attention during the last years. Several subsets of regulatory T cells were described based on their surface markers and citokine production, but nevertheless, there are no specific markers for any subsets and their classification relies on their suppression mechanism.

It is unknown which of the subgroups of regulatory T cells is more important in the prevention and control of allergic diseases, being commonly accepted its importance in homeostasis.

Key-words:
Allergic diseases
peripheral tolerance
regulatory T cells
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