Pulmonology Pulmonology
Pulmonol 2018;24:106-14 - Vol. 24 Num.2 DOI: 10.1016/j.rppnen.2017.10.007
Review
Managing latent tuberculosis infection and tuberculosis in children
I. Carvalhoa,, , D. Golettib, S. Mangac, D.R. Silvad, D. Manisseroe, G. Migliorif
a Pediatric Pulmonologist, Centro Diagnostico Pneumológico de Gaia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
b Translational Research Unit, National Institute for Infectious Diseases, Roma, Italy
c Associate Professor at Public Health and Preventive Medicine, Department San Marcos National University, Principal Professor of Infectious Diseases Lung Diseases at Hermilio Valdizan University, Peru
d Professor of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Pulmonology Division, Porto Alegre, Brazil
e Honorary Senior Lecturer, University College of London, Institute for Global Health, London, UK
f WHO Collaborating Centre for TB and Lung Diseases, Maugeri Care and Research Institute! Tradate, Italy
Received 16 October 2017, Accepted 27 October 2017
Abstract

Tuberculosis (TB) is a major cause of childhood morbidity and mortality worldwide. The aim of this review is to describe the management of the child with TB and latent tuberculosis infection (LTBI).

To develop this article, a working group reviewed relevant epidemiological and other scientific studies and established practices in conducting LBTI and TB in children. The article describes how to manage the child with LTBI, considering transmission and infectiousness of tuberculosis, contact screening and prioritization of contacts and recommendations on treatment of children with LTBI and how to manage the child with TB considering the susceptibility of children to developing tuberculosis, epidemiology and classification of tuberculosis in children, diagnosis and treatment.

Keywords
Tuberculosis, Pediatric, Childhood, Latent tuberculosis infection
Pulmonol 2018;24:106-14 - Vol. 24 Num.2 DOI: 10.1016/j.rppnen.2017.10.007